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石川  仁

氏名石川 仁
所属・職位理学療法学科・教授
学位博士(医学)
E-Mailhishikawa@
(@以下にyachts.ac.jpを加えてください)
石川仁
専門分野

 公衆衛生学、疫学

研究テーマ1.バイオマーカーの診断精度向上のための事前確率要因の検討
2.ワクチン接種率の地域間格差の要因研究
担当科目学部:リハビリテーション概論、保健医療論、成人老年疾病論 I、小児疾病論、チーム医療論、ケアシステム論、卒業研究
大学院博士前期:特別研究
教育上の能力に関する事項1.平成10年~平成17年 三重大学医学部・公衆衛生学講座・助教授
2.平成17年~平成20年 山形大学医学部・公衆衛生学講座・助教授
職務上の実績に関する事項1.平成26年~平成29年 山形県村山総合支庁・医療監(兼)村山保健所長
2.平成29年~令和2年 山形県庄内総合支庁・医療監(兼)庄内保健所長
3.医師、社会医学系指導医・専門医、日本医師会認定産業医
主な研究業績


学術論文
欧文(査読有り)
1.The Largest Measles Outbreak, Including 38 Modified Measles and 22 Typical Measles Cases in Its Elimination Era in Yamagata, Japan, 2017.
Komabayashi K, Seto J, Tanaka S, Suzuki Y, Ikeda T, Onuki N, Yamada K, Ahiko T, Ishikawa H, Mizuta K. Jpn J Infect Dis. 2018 71(6):413-418

 

2.A case of laboratory cross-contamination of Mycobacterium tuberculosis identified using comparative genomics.
Seto J, Wada T, Suzuki Y, Ikeda T, Araki K, Umetsu Y, Ishikawa H, Mizuta K, Ahiko T. Int J Tuberc Lung Dis. 2018 22(10):1239-1242

 

3.Quantitative measurement of a candidate serum biomarker peptide derived from α2-HS-glycoprotein, and a preliminary trial of multidimensional peptide analysis in females with pregnancy-induced hypertension.
Hamamura K, Yanagida M, Ishikawa H, Banzai M, Yoshitake H, Nonaka D, Tanaka K, Sakuraba M, Miyakuni Y, Takamori K, Nojima M, Yoshida K, Fujiwara H, Takeda S, Araki Y. Ann Clin Biochem. 2018 55(2):287-295

 

4.Simple quantitation for potential serum disease biomarker peptides, primarily identified by a peptidomics approach in the serum with hypertensive disorders of pregnancy.
Hamamura K, Nonaka D, Ishikawa H, Banzai M, Yanagida M, Nojima M, Yoshida K, Lee LJ, Tanaka K, Takamori K, Takeda S, Araki Y. Ann Clin Biochem. 2016 53(Pt 1):85-96

 

5.Report of a case of acinic cell carcinoma of the upper lip and review of Japanese cases of acinic cell carcinoma of the minor salivary glands.
Ishikawa S, Ishikawa H, Fuyama S, Kobayashi T, Waki T, Taira Y, Iino M. J Clin Exp Dent. 2016 8(5) e638-e644. eCollection 2016

 

6.Postnatal epigenetic modification of glucocorticoid receptor gene in preterm infants: a prospective cohort study.
Kantake M, Yoshitake H, Ishikawa H, Araki Y, Shimizu T. BMJ Open. 2014 14;4(7):e005318

 

7.Effects of occupational environmental controls and work management on chromosomal damage in dental technicians in Japan.
Ishikawa S, Ishikawa H, Shindo T, Yoshida T, Shimoyama Y, Satomi T, Fujii S, Hamamoto Y, Iino M, Fukao A. Int J Hyg Environ Health. 2013 Jan;216(1):100-7

 

8.Clinical peptidomic analysis by a one-step direct transfer technology: its potential utility for monitoring of pathophysiological status in female reproductive system disorders.
Araki Y, Nonaka D, Hamamura K, Yanagida M, Ishikawa H, Banzai M, Maruyama M, Endo S, Tajima A, Lee LJ, Nojima M, Takamori K, Yoshida K, Takeda S, Tanaka K. J Obstet Gynaecol Res. 2013 39(10):1440-8

 

9.The miR-221/222 cluster, miR-10b and miR-92a are highly upregulated in metastatic minimally invasive follicular thyroid carcinoma.
Jikuzono T, Kawamoto M, Yoshitake H, Kikuchi K, Akasu H, Ishikawa H, Hirokawa M, Miyauchi A, Tsuchiya S, Shimizu K, Takizawa T. Int J Oncol. 2013 42(6):1858-68

 

10.Overexpression of TEX101, a potential novel cancer marker, in head and neck squamous cell carcinoma.
Yoshitake H, Yokoi H, Ishikawa H, Maruyama M, Endo S, Nojima M, Yoshida K, Yoshikawa H, Suzuki F, Takamori K, Fujiwara H, Araki Y. Cancer Biomark. 2012-2013;12(3):141-8

 

11.Postoperative prophylactic effect of fondaparinux for prevention of deep venous thrombosis after cemented total hip replacement: a comparative study.
Kawaji H1, Ishii M, Tamaki Y, Hamasaki M, Ishikawa H, Sasaki K, Dairaku K, Takagi M. Mod Rheumatol. 2012 22(2):216-22 Effect of platelet-rich plasma with fibrin matrix on healing of intrasynovial flexor tendons. Sato D, Takahara M, Narita A, Yamakawa J, Hashimoto J, Ishikawa H, Ogino T. J Hand Surg Am. 2012 37(7):1356-63

 

12.Quantitative peptidomic analysis by a newly developed one-step direct transfer technology without depletion of major blood proteins: its potential utility for monitoring of pathophysiological status in pregnancy-induced hypertension.
Araki Y, Nonaka D, Tajima A, Maruyama M, Nitto T, Ishikawa H, Yoshitake H, Yoshida E, Kuronaka N, Asada K, Yanagida M, Nojima M, Yoshida K, Takamori K, Hashiguchi T, Maruyama I, Lee LJ, Tanaka K. Proteomics. 2011 11(13):2727-37

 

13.Higher efficacy of urinary bone resorption marker measurements in assessing response to treatment for osteoporosis in postmenopausal women.
Abe Y, Ishikawa H, Fukao A. Tohoku J Exp Med. 2008 214(1):51-9

 

14.Different changes in resistance index between uterine artery and uterine radial artery during early pregnancy.
Tamura H, Miwa I, Taniguchi K, Maekawa R, Asada H, Taketani T, Matsuoka A, Yamagata Y, Ishikawa H, Sugino N. Hum Reprod. 2008 23(2):285-9

 

15.Relationship between decreased expression of squamous cell carcinoma antigen 2 and E-cadherin in primary cervical cancer lesions and lymph node metastasis.
Murakami A, Nakagawa T, Fukushima C, Torii M, Sueoka K, Nawata S, Takeda O, Ishikawa H, Sugino N. Oncol Rep. 2008 19(1):99-104

 

16.Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate.
Tamura H, Takasaki A, Miwa I, Taniguchi K, Maekawa R, Asada H, Taketani T, Matsuoka A, Yamagata Y, Shimamura K, Morioka H, Ishikawa H, Reiter RJ, Sugino N. J Pineal Res. 2008 44(3):280-7

 

17.Irradiation prolongs survival of Alport mice.
Katayama K, Kawano M, Naito I, Ishikawa H, Sado Y, Asakawa N, Murata T, Oosugi K, Kiyohara M, Ishikawa E, Ito M, Nomura S. J Am Soc Nephrol. 2008 19(9):1692-700

 

18.Genotoxic effects of alcohol in human peripheral lymphocytes modulated by ADH1B and ALDH2 gene polymorphisms.
Ishikawa H, Ishikawa T, Yamamoto H, Fukao A, Yokoyama K. Mutat Res. 2007 615(1-2):134-42

 

19.Reactivation of herpes simplex virus type 1 and varicella-zoster virus and therapeutic effects of combination therapy with prednisolone and valacyclovir in patients with Bell's palsy.
Kawaguchi K, Inamura H, Abe Y, Koshu H, Takashita E, Muraki Y, Matsuzaki Y, Nishimura H, Ishikawa H, Fukao A, Hongo S, Aoyagi M. Laryngoscope. 2007 117(1):147-56

 

20.Aldo-keto reductase family 1, member B10 in uterine carcinomas: a potential risk factor of recurrence after surgical therapy in cervical cancer.
Yoshitake H, Takahashi M, Ishikawa H, Nojima M, Iwanari H, Watanabe A, Aburatani H, Yoshida K, Ishi K, Takamori K, Ogawa H, Hamakubo T, Kodama T, Araki Y. Int J Gynecol Cancer. 2007 17(6):1300-6

 

21.Gene-environmental interactions between alcohol-drinking behavior and ALDH2 and CYP2E1 polymorphisms and their impact on micronuclei frequency in human lymphocytes.
Ishikawa H, Miyatsu Y, Kurihara K, Yokoyama K. Mutat Res. 2006 594(1-2):1-9

 

22.Relationship between fetal weight, placental growth and litter size in mice from mid- to late-gestation.
Ishikawa H, Seki R, Yokonishi S, Yamauchi T, Yokoyama K. Reprod Toxicol. 2006 21(3):267-70

 

23.Genotoxic damage in female residents exposed to environmental air pollution in Shenyang city, China.
Ishikawa H, Tian Y, Piao F, Duan Z, Zhang Y, Ma M, Li H, Yamamoto H, Matsumoto Y, Sakai S, Cui J, Yamauchi T, Yokoyama K. Cancer Lett. 2006 240(1):29-35

 

24.A polymorphism of the methionine synthase reductase gene increases chromosomal damage in peripheral lymphocytes in smokers.
Ishikawa H, Ishikawa T, Miyatsu Y, Kurihara K, Fukao A, Yokoyama K. Mutat Res. 2006 599(1-2):135-43

 

25.Comparison between valsartan and valsartan plus cilnidipine in type II diabetics with normo- and microalbuminuria.
Katayama K, Nomura S, Ishikawa H, Murata T, Koyabu S, Nakano T. Kidney Int. 2006 70(1):151-6

 

26.The effects of GSTM1 and GSTT1 polymorphisms on micronucleus frequencies in human lymphocytes in vivo.
Kirsch-Volders M1, Mateuca RA, Roelants M, Tremp A, Zeiger E, Bonassi S, Holland N, Chang WP, Aka PV, Deboeck M, Godderis L, Haufroid V, Ishikawa H, Laffon B, Marcos R, Migliore L, Norppa H, Teixeira JP, Zijno A, Fenech M. Cancer Epidemiol Biomarkers Prev. 2006 15(5):1038-42

 

27.Teratogenicity and developmental toxicity of chlorpyrifos. Maternal exposure during organogenesis in mice.
Tian Y, Ishikawa H, Yamaguchi T, Yamauchi T, Yokoyama K. Reprod Toxicol. 2005 20(2):267-70

 

28.Differential regulation of apoptosis in the corpus luteum of pregnancy and newly formed corpus luteum after parturition in rats.
Takiguchi S, Sugino N, Esato K, Karube-Harada A, Sakata A, Nakamura Y, Ishikawa H, Kato H. Biol Reprod. 2004 70(2):313-8

 

29.Evidence of association of the CYP2E1 genetic polymorphism with micronuclei frequency in human peripheral blood.
Ishikawa H, Yamamoto H, Tian Y, Kawano M, Yamauchi T, Yokoyama K. Mutat Res. 2004 546(1-2):45-53

 

30.Effects of advanced maternal age on development of preimplantation mouse embryos obtained from delayed mating.
Ishikawa H, Yamauchi T. Reprod Toxicol. 2003 17(1):73-7

 

31. Analysis of teratogenic effects of maternal treatment with 2-bromopropane in mice. Ishikawa H, Yamauchi T.
J Occup Health. 2003 45(1):63-5

 

32.Influence of gender, age and lifestyle factors on micronuclei frequency in healthy Japanese populations.
Ishikawa H, Tian Y, Yamauchi T. J Occup Health. 2003 45(3):179-81

 

33.Effects of ALDH2 gene polymorphisms and alcohol-drinking behavior on micronuclei frequency in non-smokers.
Ishikawa H, Yamamoto H, Tian Y, Kawano M, Yamauchi T, Yokoyama K. Mutat Res. 2003 541(1-2):71-80

 

34.Localization of GPI-80, a beta2-integrin-associated glycosylphosphatidyl-inositol anchored protein, on strongly CD14-positive human monocytes.
Sendo D, Takeda Y, Ishikawa H, Sendo F, Araki Y. Immunobiology. 2003 207(3):217-21

 

35.Micronucleus assay of human lymphocytes: a comparison of cytokinesis-block and human capillary blood lymphocytes methods.
Tian Y, Ishikawa H, Piao FY, Yamamoto H, Yamauchi T, Duan ZW, Zhang YM, Ma MY, Cui JS. J Occup Health. 2003 45(6):408-9

 

36.Induction of micronuclei formation in preimplantation mouse embryos after maternal treatment with 2-bromopropane.
Ishikawa H, Tian Y, Yamauchi T. Reprod Toxicol. 2001 15(1):81-5

 

37.Analysis of cytogenetic and developmental effects on pre-implantation, mid-gestation and near-term mouse embryos after treatment with trichlorfon during zygote stage.
Tian Y, Ishikawa H, Yamauchi T. Mutat Res. 2000 471(1-2):37-44

 

38.Developmental retardation of XO mouse embryos at mid-gestation.
Ishikawa H, Banzai M, Yamauchi T. J Reprod Fertil. 1999 115(2):263-7

 

39.Analysis of colchicine-induced chromosomal aberrations in embryos obtained from XO mice.
Ishikawa H, Endo A. Reprod Toxicol. 1998 12(2):115-8

 

40.A 39,X/40,XY true hermaphrodite mouse with normal ovarian function.
Ishikawa H, Sakurada K, Fujita T, Yamauchi T. Reprod Fertil Dev. 1997 9(8):775-9

 

41.Prolongation of duration of ovulation in ageing mice.
Ishikawa H, Endo A. J Reprod Fertil. 1996 108(2):167-70

 

42.Cytogenetic effects of advanced maternal age and delayed fertilization on first-cleavage mouse embryos.
Sakurada K, Ishikawa H, Endo A. Cytogenet Cell Genet. 1996;72(1):46-9

 

43.Neonatal mouse hip joint and hindlimb anomalies induced by prenatal exposure to Ara-C.
Chiba K, Ishikawa H, Rahman ME, Endo A. Reprod Toxicol. 1996 10(3):215-9

 

44.Carpal and tarsal bone development is highly sensitive to three antiproliferative teratogens in mice. Rahman ME, Ishikawa H, Watanabe Y, Endo A. Reprod Toxicol. 1996 10(6):485-9

 

45.Combined effects of maternal age and delayed fertilization on the frequency of chromosome anomalies in mice.
Ishikawa H, Endo A. Hum Reprod. 1995 10(4):883-6

 

46.Viability, development and incidence of chromosome anomalies of preimplantation embryos from XO mice.
Banzai M, Omoe K, Ishikawa H, Endo A. Cytogenet Cell Genet. 1995 70(3-4):273-7

 

47.Stage specificity of Ara-C induced carpal and tarsal bone anomalies in mice.
Rahman ME, Ishikawa H, Watanabe Y, Endo A. Reprod Toxicol. 1995 9(3):289-96

 

48.The Timing of Appearance of Ossification Centers of Carpal and Tarsal Bones in Mouse Newborns.
Chiba K, Rahman ME, Ishikawa H, Endo A. Cong Anom 1995 35(2): 189-197

 

49.Carpal and tarsal bone anomalies in mice induced by maternal treatment of Ara-C.
Rahman ME, Ishikawa H, Watanabe Y, Endo A. Reprod Toxicol. 1994 8(1):41-7

 

50.Decreased teratogen susceptibility in mouse fetuses obtained from delayed mating.
Ishikawa H, Endo A. Reprod Toxicol. 1993 7(5):423-7

 

51.Ecological factors affecting body size of Japanese adolescents.
Endo A, Omoe K, Ishikawa H. Am J Phys Anthropol. 1993 91(3):299-303

 

52.Compensatory development in preimplantation mouse embryos derived from delayed mating.
Ishikawa H, Omoe K, Endo A. Biol Reprod. 1992 47(5):782-4

 

53.Growth and differentiation schedule of mouse embryos obtained from delayed matings.
Ishikawa H, Omoe K, Endo A. Teratology. 1992 45(6):655-9

 

和文(査読有り)
1.東日本大震災と深部静脈血栓症 - 被災後入院患者の検討 -
廣岡茂樹, 外田洋孝, 小林夕里子, 石川 仁, 折田博之
静脈学 23巻1号: 13-16、2012年

 

2.東日本大震災と深部静脈血栓症 - 40歳以上の女性避難者の危険因子の検討 -
廣岡茂樹, 石井正次, 外田洋孝, 石川 仁, 折田博之
静脈学 23巻3号: 255-259、2012年

 

3.地域住民における喫煙習慣と栄養素ならびに食品群摂取量との関連
矢口 (田中) 友理, 石川 仁, 邵 力, 佐々木 敏, 深尾 彰
日本栄養・食糧学会誌 64 巻 3 号 159-167、2011年

 

4.生活習慣病予防における健康行動とソーシャルサポートの関連
高橋 和子, 工藤 啓, 山田 嘉明, 邵 力, 石川 仁, 深尾 彰
日本公衆衛生雑誌 55巻8号491-502、2008 年

 

和文(査読無し)
1.労働者の問題飲酒行動是正のための遺伝子多型情報を用いた介入研究
石川 仁
産業医学ジャーナル32巻3号 51-52、2009年

 

2.日本人高校生の体格と体型の年次推移
遠藤 晃, 石川 仁, 千葉克司, 重茂克彦
日本医事新報 (3628): 48-50, 1993年

 

3. 0/100は安全か? 
遠藤 晃 , 石川 仁
医学のあゆみ 161巻6号: 430-431, 1992年