山下　隆夫 — 公立大学法人 山形県立保健医療大学
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山下　隆夫

山下　隆夫

e-mail
 メールtyamashita@yachts.ac.jp
所属
 看護学科
担当科目
 病原微生物学、生体防御学
専門
 免疫学・寄生虫学
専門研究分野
 ・　腫瘍および原虫の増殖抑制におけるＮＯの役割
・　好中球の抗腫瘍作用
・　寄生虫感染におけるサイトカインネットワーク
・　寄生虫症の簡易診断法の開発
主な業績
著 書
  1. 山下隆夫、仙道富士郎
    NEW　寄生虫病学.　蠕虫のエスケープ機構（小島荘明　編）、南江堂、東京、1993、ｐ１１６

論 文

  1. 佐藤良也、鈴木俊夫、山下隆夫、白木公、関川弘雄、大鶴正満. 1973. アニサキス症の免疫学的診断における蛍光抗体法の応用（１）抗原の作製法について.寄生虫学雑誌, 22, 249 - 258.　
  2. 佐藤良也、鈴木俊夫、山下隆夫、関川弘雄、大鶴正満、陳秀男、李松玉、劉国輝. 1974 . 広東住血線虫症の免疫診断に関する研 (4)Immunoadsorbent を用いた抗原の精製. 寄生虫学雑誌,23, 42 - 52.
  3. Suzuki, T., Y. Sato, T. Yamashita, H. Sekikawa, and M. Otsuru. 1974. Anisakiasis: Preparation of a stable antigen 　for indirect fluorescent antibody test. Exp. Parasitology , 35, 418 -428 .
  4. 佐藤良也、鈴木俊夫、白木公、山下隆夫、大鶴正満. 1974.　 アニサキス症の免疫学的診断法に関する研究（4）幼虫ヘモグロビンの抗原特異性ならびにImmunoadsorbentを用いた非特異成分の吸収除去について.寄生虫学雑誌, 23, 356 - 365.
  5. 佐藤良也、山下隆夫、大鶴正満、鈴木俊夫、 浅石和昭、西野千郷.1975.　アニサキス症の発症機序の解析　1.消化管のアナフラキシー反応. 寄生虫学雑誌, 24, 192 - 202.
  6. Suzuki, T., Y. Sato, T. Yamashita, H. Sekikawa,　and M. Otsuru. 1975. Angiostrongylus cantonensis:Preparation of a specific　antigen using immunosorbent columns.Exp. Parasitology , 38, 191 - 201.
  7. 山下隆夫、佐藤良也、、白木公、大鶴正満、鈴木俊夫.1975.　広東住血線虫の ラット、マウス、モルモット体内における発育. 寄生虫学雑誌, 24, 114 - 121.
  8. 山下隆夫、佐藤良也、、大鶴正満.1976.　糸状虫症の間接赤血球凝集反応用抗原の精製　(1)犬糸状虫感染血清における検討.　寄生虫学雑誌, 25, 87-93.　
  9. 山下隆夫、斉藤豐、佐藤良也、大鶴正満、鈴木俊夫. 1978. 奄美諸島ー与論島に おける広東住血線虫の調査. 寄生虫学雑誌,　27, 143 - 150.
  10. Yamashita, T., Y. Saito, Y. Sato, A. Takai,H. Watanabe, and M. Otsuru . 1979. Circulating antigens and immune complexes in the serum of rat infected with Angiostrongylus cantonensis. Jap. J. Parasit., 28, 393 - 401.
  11. 高井昭彦、佐藤良也、渡辺久実、大鶴正満、山下隆夫. 1979. 広東住血線虫感染ラット血清に認められる免疫複合体ー免疫複合体中の広東住血線虫抗原の検出について. 寄生虫学雑誌, 28, 411 - 420.
  12. 佐藤良也、高井昭彦、渡辺久実、大鶴正満、山下隆夫. 1980. 広東住血線虫感染ラット血清に認められる免疫複合体ー免疫複合体と感染幼虫数との関連. 寄生虫学雑誌. 29, 257- 265.
  13. Sato, Y., M. Otsuru, R. Asato, and　T. Yamashita .1981. An epidemiological survey on Angiostrongylus cantonensis and angiostrongyliasis in the southwest island , Japan . Ryukyu University, J. Health Sciences and Medicine, 4, 15 - 26.
  14. 鈴木俊夫、赤尾信明、山下隆夫. 1981. 非標識抗体酵素法による組織内寄生虫同定の試み（２）蠕虫. 寄生虫学雑誌, 30, 517- 526.
  15. Saito, Y., T. Watanabe, and T. Yamashita. 1982. Two new intestinal trematodes, Macroorchis chimarrogalus N. sp. and Macroorchis elongatus N. sp. from japanese water shrew and others, with a description of the metacercaria of Macroorchis chimarrogalus N.sp.(Trematoda:Nanophyetidae). Acta Medica et Biologica, 30, 47 - 56.
  16. Saito, Y., S. Saito, T. Yamashita,　T. Watanabe, and H. Sekikawa1982. On　 Nanophyetus japonensis N.sp. from northern district, honsu, Japan (Trematoda: Nanophyetidae). Acta . Medica et Biologica, 30, 1 - 15.
  17. 斉藤豊、山下隆夫、渡辺正、斉藤奨、西塚胞喜、相川勝吾、大山忍、片桐進. 1982 . 　山形県における恙虫調査と恙虫病リケッチア　Rickettsia tsutsugamushi の分離. 山形衛研所報, 15, 37 - 43.
  18. 斉藤奨、山下隆夫、渡辺正、岸由紀子、設楽明美、仙道富士郎. 1983. ツツガムシの生息状況および野ネズミの恙虫病リケッチア保有状況に関する調査. 山形県医師会報, 382, 1-6.
  19. Yamashita, T. 1984. Studies on the immune responsiveness in mice infected with ,Toxocara canis, Ascaris suum and Angiostrongylus cantonensis. Acta Medica et Biologica, 32, 1 -22.
  20. 斉藤奨、渡辺正、山下隆夫. 1984. 山形県における淡水漁媒介性人体寄生虫の疫学的研究. 山形医学, 2, 71 - 79.
  21. 斉藤奨、山下隆夫、渡辺正、仙道富士郎、布山繁美. 赤尾信明. 1984. 山形県で見出された肺犬糸状虫症の１例について. 臨床外科, 39, 1309-1312.
  22. Kimura, S., K. Umetsu,T. Yamashita, T. Suzuki, S. Arai, and F. Sendo. 1987.　Tcell mitogenicity of a novel b - Dーgalactoside specific lectin from the beetle, Allomyrina dichotoma　(allo A). Immunopharmacology ,13, 181-188.
  23. Araki, Y., S. Kurata, T. Oikawa,T. Yamashita,M. Hiroi, M. Naiki, and F. Sendo. 1987. A monoclonal antibody reacting with the zona pellucida of the oviductal egg but not with that of the ovarian egg of the golden hamster. J. Reproductive Immunology, 11, 193-208.
  24. Yamashita, T., T. Watanabe, and F. Sendo. 1987. Studies on the immunological disturbance in murine Schistosomiasis japonica from the viewpoint of the interleukin cascade reaction. Immunology, 62, 215 - 221.
  25. Kimura, S., T. Inoue, T. Yamashita, Y. Midorikawa,S. Arai, and F. Sendo. 1987. Production of factor(s) thatrender polymorphonuclear leukocytes cytostatic from spleen cells stimulated with a Streptococcal preparation, OK-432. Cancer Research, 47, 6204-6209.
  26. Sakai, Y., Y. Araki, T. Yamashita, S. Kurata, T. Oikawa,　M. Hiroi, and F. Sendo. 1988. Inhibition of 　in vitro fertilization　by a monoclonal antibody reacting with the zona pellucida of the oviductal egg but not with that of the ovarian egg of the golden hamster. J. Reproductive Immunology, 14, 177 - 189.
  27. Miyake, Y., S. Ajitsu, T. Yamashita, and F. Sendo.　1988. Enhancement by recombinant interferon-g of spontaneous tumor cytostasis by human neutrophils. Mol. Biother.,1, 37 - 42.
  28. Umetsu, K.., I. Yusa, T. Yamashita, S. Saito,　T. Yamaguchi, S. B. Ellepola,T. Ishida, and T. Suzuki. 1989.　Genetic polymorphisms of orsomucoid and alph-2-HS glycoprotein in Thai , Srilankan and Paraguayan populations. Genet. Jpn. J. Human, 34, 195 - 202.
  29. Sakai, Y., S. Kimura, T. Yamashita, K. Umetsu,　T. Suzuki, and F. Sendo.　1989. A sensitive IL-1 thymocyte costimulator assay using a novel b-D-galactoside specific lectin from the beetle, Allomyrian dichotoma.　Microbiol. Immunol.,33, 569 - 577.
  30. Yamashita, T., T. Watanabe, Y. Hosaka, H. Asahi,　M. Minai, S. Saito, and F. Sendo. 1989. Immunological studies on Schistosomiasis japonica using hybridoma technology (1) Characterization of two monoclonal antibodies obtained from spleen cells of Schistosoma japonicum infected mice, reactive with a Schistosoma japonicum egg antigen or a heterophil antigen. Jpn. J. Parasitol., 38, 307 - 315.
  31. Atsumi, M., Y. Araki, Yamashita, T., T. Watanabe,　S. Saito, and F. Sendo.1989 . Immunological studies　on Schistosomiasis japonica using hybridoma　technology(II) Immunohistochemical reactivity with the nervous systems and the stomach glandular cells of aheterophil monoclonal antibody obtained from spleen cells of Schistosoma japonicum infected mice.Jpn. J. Parasitol., 38, 316 - 323.
  32. Sekiya, S., and S. Gotoh, T. Yamashita, T. Watanabe, S. Saito and F. Sendo. 1989. Selective depletion of rat neutrophils by in vivo administration of a monoclonal antibody. J. Leukocyte Biol., 46, 96 - 102.
  33. Yamashita, T., and D. L. Boros, 1990. Changing patterns of lymphocyte proliferation, IL-2 production and utilization, and IL-2 receptor expression in mice infected with Schistosoma mansoni. J. Immunology, 145, 724-731.
  34. Watanabe, T., T. Yamashita, and F. Sendo. 1990. Suppression of macrophage-mediated antibody dependent killing of Schistosoma mansoni larvae by concanabalin A stimulated spleen cell derived factor(s). Parasite Immunology, 12, 309-319.
  35. Midorikawa, Y., T. Yamashita, and F. Sendo. 1990. Enhancement of interleukin 1 release from rat macrophages by treatment with proteolytic enzymes. Yamagata Med. J., 8, 95-107.
  36. Midorikawa, Y., T. Yamashita, and F. Sendo. 1990. Modulation of the immune response to transplanted tumors in rats by selective depletion of neutrophils in vivo using a monoclonal antibody : abrogation of specific transplantation residence to chemical carcinogen induced syngeneic tumors by selective depletion of neutrophils in vivo. Cancer Research, 50, 6243-6247.
  37. Sekiya, S., T. Yamashita, and F. Sendo. 1990. Suppression of late phase enhanced vascular permeability in rats by selective depletion of neutrophils with a monoclonal antibody. J. Leukocyte Biology, 48, 258-265.
  38. Abe, Y., S. Sekiya, T. Yamashita, and F. Sendo. 1990. Vascular hyperpermeability induced by tumornecrosis factor and its augmentation by IL-1 and IFN-g is inhibited by selective depletion of neutrophils with a monoclonal antibody. J. Immunology, 145, 2902-2907.
  39. Rojekittikhun, W., S. Saito, T. Yamashita, T. Watanabe, P. Setasuban, and F. Sendo. 1991. Three monoclonal antibodies specific to Gnathostoma spinigerum . Jpn. J. Parasitol.,40, 287 -292.
  40. Yamashita, T., and D. L. Boros. 1992. IL-4 influences IL-2 production and granulomatous inflammation in murine schistosomiasis mansoni. J. Immunology, 149, 3659-3664.
  41. Umetsu, K., K. Yamashita, J. Suzuki, T. Yamashita, and T. Suzuki. 1993 . Purification and Characterization of an N-Acetillactosamine Specific Lectin from Larvae. Archives of Biochemistry and Biophysics, 30, 200 - 205.
  42. Kudo, C., T. Yamashita, A.. Araki, M. Terashita, T. Watanabe, M. Atsumi, M. Tamura, and F. Sendo. 1993 . Modulation of in vivo immune response by selective depletion of neutrophils using a monoclonal antibody, RP-3 . I . Inhibition by RP-3 treatment of the priming and effector phases of delayed type hypersensitivity to sheep red blood cells in rats. J. Immunology, 150, 3728-3738.
  43. Kudo, C., T. Yamashita, M. Terashita, and F. Sendo. 1993 . Modulation of in vivo immune response by selective depletion of neutrophils using a monoclonal antibody, RP-3 . I I. Inhibition by RP-3 treatment of mononuclear leukocyte recruitment in delayed type hypersensitivity to sheep red blood cells in rats. J. Immunology, 150, 3739-3746.
  44. Takeda, Y., H. Watanabe, S. Yonehara, T. Yamashita, S. Saito, and F. Sendo. 1993. Rapid acceleration ofneutrophil apoptosis by tumor necrosis factor -a. International Immunology, 5, 691 - 694
  45. Yamashita, T., T. Watanabe, S. Saito, Y. Araki, and F. Sendo.1993. Schistosoma japonicum soluble egg antigens activate naive B cells to produce antibodies: definition of parasite mechanisms of immune deviation. Immunology, 79, 189 - 195.
  46. Rojekittikhum , W., S. Saito, T. Yamashita, T. Watanabe, and F. Sendo. 1993. Immunohistochemical localization of Gnathostoma spinigerumlarval antigens by monoclonal antibodies: I. light microscopy . Southeast Asian J. Trop. Med. Public Health, 24, 494 - 500.
  47. Rojekittikhum , W., T. Yamashita, S. Saito, T. Watanabe, T. Azuma, and F. Sendo. 1993. Purification of Gnathostoma spiningerum larval antigens by monoclonal antibody affinity chromatography. Southeast Asian J. Trop. Med. Public Health, 24, 680 - 684.
  48. Yamashita, T., H. Watanabe, M. Maldonado, M. A. Leguizamon, T. Watanabe, S. Saito, T. Shozawa, Y. Sato , and F. Sendo. 1994. The gelatin particle indirect agglutination test, a means of simple and sensitive serodiagnosis of chagas' desease. Jpn. J. Trop. Med. Hyg., 22, 5 - 8.
  49. Saito, S. ., W.. Rojekittikhum , P. Gao , T. Yamashita, T. Watanabe, N. Sakato, and F. Sendo. Characterization of the recognition specificity of autoreactive, polyspecificmonoclonal antibodies obtained from spleen cells of parasite infected BALB/c mice. 1994. Parasite Immunology, 16, 609-617.
  50. Toma, H., J. Kobayashi, M. E. Guariento, E. A. de Almedia, Y. Sato, and T. Yamashita. 1994. Evaluation of gelatin particle indirect agglutination test for serodiagnosis of Chagas' disease. Jpn. J. Parasitol., 43, 237-245.
  51. Saito, S. ., W. Rojekittikhum , P. Gao , T. Yamashita, T. Watanabe, N. Sakato, and F. Sendo. 1994. Monoclonal antibodies to Trichinella spiralis muscle larvae that mimic serum antibody from Trichinellosis mice and discriminates various isolates of the worm. Parasite Immunology,16, 265-273.
  52. Murata, K., T. watanabe, T. Yamashiyta, S. Gon, and F. Sendo. 1995. Modulation of rat neutrophil functions by administration of granulocyte colony stimulating factor. J. Leuko. Bio.logy, 57, 250-256.
  53. 梅津和夫、山下隆夫、鈴木淳一、丁　梅、鈴木庸夫.1995.カブトムシ体液中に 見出されたGalNAcal-3Gal結合レクチン. 山形医学, 13, 59- 656.
  54. Hachiya, O., Y. Takeda, H. Miyata, H. Watanabe, T. Yamashita, and F. Sendo. 1995. Inhibition by bacterial lipopolysaccharide of spontaneous and TNF-a induced human neutrophil apoptosis in vitro. Microbiol. Immunol., 39, 715- 723.
  55. Terashita, M., C. Kudo, T. Yamashita, I. Gresser, and F. Sendo. 1996. Enhancement of delayed type hypersensitivity to sheep red blood cells in mice by granulocyte colony stimulating factor administration at the elicitation phase. J. Immunol., 156, 4638-4643.6.
  56. Sato, T., Y. Midorikawa, T. Yamashita, A. Araki, and F. Sendo. 1996. The neutrophil as an information transmitter in tumor inhibition by a streptococcal biological response modifier, OK-432. Cancer Immunol Immunother., 43, 77-86.6.
  57. Bosompem, K. M., T. Arishima, T. Yamashita, I. Ayi, W. K. Anyan and S. Kojima. 1996. Extraction of Schistosoma haematobium antigens from infected human urine and generation of potential diagnostic monoclonal antibodies to urinary antigens. Acta Tropica 62, 91-103.
  58. Ohtake, K., H. Takei, T. Watanabe, Y. Sato, T. Yamashita, K. Sudo, M. Kuroki, J. Chihara, and F. Sendo. 1997. A monoclonal antibody modulates neutrophil adherence while enhancing cell motility. Microbiol . Immunol ., 41, 67-72 .6.
  59. Yamashita, T., T. Uchida, A. Araki, and F. Sendo. 1997. Nitric oxide is an effector molecule in inhibition of tumor cell growth by rIFN-g -activated rat neutrophils. Int. J. Cancer, 71, 223-230.6.
  60. Uchida, T., T. Yamashita, A. Araki, and F. Sendo. 1997. rIFN-g -activated rat neutrophils induce tumor cell apoptosis by nitric oxide. Int. J. Cancer, 71, 231-236.6.
  61. Jing, T., S. Saito, T. Yamashita, T. Watanabe, and F. Sendo. 1998. Immunohistochemical localization in the Echinococcus multilocularis (Em) infected liver of Em antigens reactive with monoclonal antibodies (mAbs) raised against protoscolices. Yamagata Med. J. 16, 15-29.
  62. Chen, L., P. Gao, T. Yamashita, T. Nara, S. Kojima, F. Sendo, Y. Araki. 1998. Molecular cloning and expression of a Schistosoma japonicum tegmental membrane-associated antigen from Japanese strain. Parasitology International 47, 289-300.
  63. Suzuki, K., T. Watanabe, S. Sakurai, K. Ohtake, T. Kinoshita, A. Araki, T. Fujita, H. Takei, Y. Takeda, Y. Sato, T. Yamashita, Y. Araki, and F. Sendo. 1999. A novel glycosylphosphatidyl inositol-anchored protein on human leukocytes: A possible role for regulation of neutrophil adherence and migration. J. Immunology , 162, 4277-4284.
  64. Yamashita, T., H. Miyata, C. Miyaji, H. Watanabe, T. Abo, T. Kobayakawa, A. Kaneko and F. Sendo. 1999. CD4+ and/or gd+ T cells in the liver spontaneously produce IL-4 in vitro during the early phase of Leishmania major infection in susceptible BALB/c mice. Acta Tropica, 73, 109-119.

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